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This Concept Map, created with IHMC CmapTools, has information related to: Biochem - G6PD, hemoglobin when denatured is a Heinz Bodies, Rigidity of cell membrane leads to extravascular hemolysis, NADPH which is consumed by glutathione reduction reaction, unconjugated bilirubin is not water soluble, extravascular hemolysis caused by digestion of RBC by macrophage, Patient in Case 1 50 yr old female has defect in pentose phosphate pathway, pentose phosphate pathway rate-limiting enzyme is Glucose 6 Phosphate Dehydrogenase, Heinz Bodies chronic production of causes extravascular hemolysis, biliverdin converted to unconjugated bilirubin, Total Serum bilirubin 19 mg/dL caused by high levels of unconjugated bilirubin, digestion of RBC by macrophage in the spleen, peroxide denatures membrane proteins, Patient in Case 1 50 yr old female presents with Anemia, Glucose 6 Phosphate Dehydrogenase deficiency of results in increase in peroxide, Patient in Case 1 50 yr old female presents with Total Serum bilirubin 19 mg/dL, hemoglobin broken down into amino acids, Heinz Bodies bind to cell membrane causing Rigidity of cell membrane, conjugated bilirubin secreted in urine and feces, hemoglobin broken down into heme, Glucose 6 Phosphate Dehydrogenase deficiency of results in decrease in NADPH